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Valentina Carlile Osteopata
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What is Gilbert syndrome and what are its symptoms?

What is Gilbert syndrome and what are its symptoms?

Gilbert's syndrome is a hereditary and benign liver disorder characterized by a genetic mutation that affects the production of the enzyme that converts indirect bilirubin into direct, resulting in the accumulation of indirect bilirubin in the blood. Bilirubin is that yellow-orange pigment that derives from the normal aging process of red blood cells, it is a waste product and, as such, must be eliminated from the body.


The signs that lead to the diagnosis of Gilbert's syndrome are:

• Absence of other liver pathologies

• Recurrent indirect hyperbilirubinemia (normal values are 0.2-0.8mg/dl)

• Normal liver function markers

The diagnosis can be carried out using molecular biology techniques, in order to verify its presence at a genetic level.


Gilbert's syndrome is in most cases asymptomatic, with symptoms that can appear temporarily, even in the presence of stress, dehydration, intense physical exercise, or the menstrual cycle.

What may appear is:

• Jaundice in correspondence with the phases of increased indirect bilirubin

• Sub-jaundice at the level of the ocular sclera

• Tiredness

• Abdominal pain

• Itching

• Difficulty concentrating

Pharmacological therapy, when administered, involves the use of barbiturates for jaundice or phytotherapeutic remedies to support liver function, such as dandelion, turmeric, boldo, artichoke.


Valentina Carlile - Osteopath expert in Osteopathy applied to voice and speech disorders since 2002. For information and reservations visit the page Contacts

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